Does Doxie One support my Chromebook (Chrome OS)?

Yes, to an extent. Doxie One saves scans as JPEG files and effectively works like a digital camera, so Chrome OS will recognize it as such and offer to let you browse your scans, like camera images. You can also use an SD card for this purpose.

The downside of simply browsing images from Doxie directly is that you’re not using our Doxie app, so you won’t get the benefits of cleaned up images, auto-contrast, creating multi-page searchable PDFs, sending to the cloud, etc. There's no Doxie app for Chrome OS.

For more information on accessing external volumes in Chrome OS, see this article.